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Synthesis of 28,29-Bisnor-(±)-Kijanolide

Book ID
104229679
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
40 KB
Volume
30
Category
Article
ISSN
0040-4039

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Synthesis of 28,29-bisnor-(±)-kijanolide
Synthesis of 28,29-bisnor-(±)-kijanolide
✍ Kei Takeda; Shin-go Yano; Eiichi Yoshii 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 244 KB

0(26)-Methyl-28,29-bisnor-(+)-kijanolide (23) has been synthesized via aldol reaction of spirotetronate 3 with octahydronaphthalene aldehyde 4 and subsequent macrocyclization of the resulting product. Kijanolide (1) and tetronolide (2), the aglycons of novel macrocyclic antitumor antibiotics kijanim

Diastereoselective synthesis of the top
Diastereoselective synthesis of the top half of kijanolide
✍ William R. Roush; Bradley B. Brown 📂 Article 📅 1989 🏛 Elsevier Science 🌐 French ⚖ 278 KB

A highly ciiasfereoselective synthesis of the top ha/f (4) of kijanolide is described. The key step is fhe exo and diastereoface selective Die/s-Alder reaction of triene 6 and chiral dienophile 6.