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Diastereoselective Synthesis of the C(17)−C(28) Fragment (The C−D Spiroketal Unit) of Spongistatin 1 (Altohyrtin A) via a Kinetically Controlled Iodo-Spiroketalization Reaction

✍ Scribed by Holson, Edward B.; Roush, William R.


Book ID
127360932
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
87 KB
Volume
4
Category
Article
ISSN
1523-7060

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Short Diastereoselective Synthesis of th
✍ Dr. Christopher L. Flowers; Prof. Dr. Pierre Vogel 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 370 KB 👁 1 views

## Abstract A unique and practical synthetic sequence for rapid access to polyketides and to further the spiroacetals derived from them, which utilizes a bidirectional Hosomi–Sakurai allylation approach around key allylsilanes in the synthesis of the AB and CD ring systems of spongistatin 1 and 2,