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Diastereoselective Synthesis of syn -1,3-Diols by Titanium-Mediated Reductive Coupling of Propargylic Alcohols

โœ Scribed by Tian, Guo-Qiang; Kaiser, Thomas; Yang, Jiong


Book ID
121377444
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
158 KB
Volume
12
Category
Article
ISSN
1523-7060

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Highly Stereoselective Synthesis of syn-
โœ Judit Esteve; Sรฒnia Matas; Miquel Pellicena; Javier Velasco; Pedro Romea; Fรจlix ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 1 views

## Abstract A sequential transformation based on a titaniumโ€mediated aldol reaction from chiral ฮฑโ€__tert__โ€butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH~4~ provides a straightforward access to __syn__โ€1,3โ€diols. These diols, containing up to three new ster