Michael reaction of macrocyclic ketene silyl acetals or a-enones occurs smoothly under electron transfer conditions while the reaction of 6-membored analogs is more sluggish, indicating the importance of the ring flexibility to allow the a,~-carbon-carbon bonds of both reaction components to rotate
โฆ LIBER โฆ
Diastereoselective Mukaiyama-Michael reaction of O,S-ketene silyl acetal
โ Scribed by Yukihiro Fujita; Junzo Otera; Shunichi Fukuzumi
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 624 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0040-4020
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SmI2-promoted conjugate reduction of ~-unsaturated esters and ketones txoceeds in a manner quite similar to Mukaiyama-Michael reaction of ketene silyl acetal. The more substituted