Mukaiyama-Michael reaction of cyclic ket
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Yukihiro Fujita; Shunichi Fukuzumi; Junzo Otera
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Article
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1997
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Elsevier Science
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French
โ 164 KB
Michael reaction of macrocyclic ketene silyl acetals or a-enones occurs smoothly under electron transfer conditions while the reaction of 6-membored analogs is more sluggish, indicating the importance of the ring flexibility to allow the a,~-carbon-carbon bonds of both reaction components to rotate