Diastereoselective Hydrocyanation of Chiral Nitrones. Synthesis of Novel α-(Hydroxyamino) Nitriles
✍ Scribed by Merino, P.; Lanaspa, A.; Merchan, F. L.; Tejero, T.
- Book ID
- 127274026
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 215 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract An efficient methodology for the synthesis of α‐aminophosphonates has been developed taking advantage of the __tert__‐butyldimethylsilyl triflate activated addition of diethyl phosphite to __N__‐benzyl nitrones derived from chiral α‐alkoxy and α‐(Boc‐amino) aldehydes. The stereoselectiv
1,3-Asymmetric induction in the Et 2 Zn-catalyzed addition of terminal alkynes was studied with nitrones bearing a chiral auxiliary on their nitrogen atom. The obtained propargylic N-hydroxylamines were generally isolated in good yields and with satisfactory to excellent diastereoselectivities.