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A New and Expedient Diastereoselective Synthesis of α-(Hydroxyamino)phosphonates and α-Aminophosphonates by Silyl Triflate Promoted Diethyl Phosphite Addition to Chiral N-Benzyl Nitrones.

✍ Scribed by Carmela De Risi; Daniela Perrone; Alessandro Dondoni; Gian Piero Pollini; Valerio Bertolasi


Publisher
John Wiley and Sons
Year
2003
Weight
177 KB
Volume
34
Category
Article
ISSN
0931-7597

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A New and Expedient Diastereoselective S
✍ Carmela De Risi; Daniela Perrone; Alessandro Dondoni; Gian Piero Pollini; Valeri 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB

## Abstract An efficient methodology for the synthesis of α‐aminophosphonates has been developed taking advantage of the __tert__‐butyldimethylsilyl triflate activated addition of diethyl phosphite to __N__‐benzyl nitrones derived from chiral α‐alkoxy and α‐(Boc‐amino) aldehydes. The stereoselectiv