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Diastereoselective bromine/lithium-exchange applied to the synthesis of a C-1/C-9-segment of the bryostatins

โœ Scribed by Reinhard W Hoffmann; Hans Christian Stiasny

Book ID
103411032
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
283 KB
Volume
36
Category
Article
ISSN
0040-4039

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Synthesis of the C1๎—ธC9 segment of epothi
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โœ Eckhard Claus; Axel Pahl; Peter G. Jones; Hartmut M. Meyer; Markus Kalesse ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 174 KB

The CI-C9 segment of epothilons was generated by an aldol reaction between chiral aldehyde 3 and ethyl ketone 4. Removal of the TBS protecting groups and debenzylation generated spiro ketal 13 which was analyzed by X-ray crystallography.