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Diastereoselective and one-pot synthesis of trans-isoquinolonic acids via three-component condensation of homophthalic anhydride, aldehydes, and ammonium acetate catalyzed by aspartic acid

✍ Scribed by Ghorbani-Choghamarani, Arash; Hajjami, Maryam; Norouzi, Masoomeh; Abbasityula, Yunes; Eigner, Václav; Dušek, Michal

Book ID
120445591
Publisher
Elsevier Science
Year
2013
Tongue
French
Weight
771 KB
Volume
69
Category
Article
ISSN
0040-4020

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## Abstract magnified image A mild and stereoselective three‐component one‐step synthesis of __cis__‐isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in