A stereoselective three-component reaction: One-pot synthesis of cis-isoquinolonic acids catalyzed by silica sulfuric acid under mild and heterogeneous conditions

✍ Scribed by Javad Azizian; Ali A. Mohammadi; Ebrahim Soleimani; Ali R. Karimi; Mohammad R. Mohammadizadeh

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2006
• Tongue: English
• Weight: 65 KB
• Volume: 43
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570430129

✦ Synopsis

Abstract

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A mild and stereoselective three‐component one‐step synthesis of cis‐isoquinolonic acid using silica sulfuric acid as a heterogeneous catalyst from an aldehyde, amine and homophthalic anhydride in acetonitrile is described. This new method produces pure products in high yields (81‐91%).