One-Pot Synthesis of cis-Isoquinolonic Acid Derivatives via Three-Component Reaction of Homophthalic Anhydride with Aldehydes and Amines using Ytterbium(III) Triflate as Catalyst
✍ Scribed by Limin Wang; Jijun Liu; He Tian; Changtao Qian; Jie Sun
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 92 KB
- Volume
- 347
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Ytterbium(III) triflate efficiently catalyzes the one-pot reaction of homophthalic anhydride with aldehydes and amines at ambient temperature to afford the corresponding cis-isoquinolonic acid derivatives in good to excellent yields with high diastereoselectivity. This method provides a novel and much improved modification of the three-component reaction in terms of mild reaction conditions, short reaction times, clean reaction profiles, small quantity of catalyst, and simple work-up procedure. Another important feature of this method is that the catalyst can be easily recovered from the aqueous layer after the reaction and can be reused with no loss of activity.