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Diastereoselective addition of hypophosphorous acid to N-(R)-α-methylbenzyl-substituted schiff bases

✍ Scribed by Jarosław Lewkowski; Rafał Karpowicz; Małgorzata Rybarczyk

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
102 KB
Volume
19
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The addition of hypophosphorous acid to an azomethine bond of N‐(R)‐α‐methylbenzyl Schiff bases of a variety of aldehydes led to the formation of N‐(R)‐α‐methylbenzylamino‐(S)‐methanephosphonous acids in 100% diastereoselectivity. This fact allows us to suggest the probable mechanism of the Strecker‐like reaction between hypophosphorous acid, an aldehyde, and (R)‐α‐methylbenzylamine. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:35–37, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20406

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