Diastereoselective 1,4-Addition of Stannyl Radical in the Presence of Lewis Acid: A Novel Synthetic Route to Optically Active β-Stannyl Esters
✍ Scribed by Nishida, Mayumi; Nishida, Atsushi; Kawahara, Norio
- Book ID
- 125959610
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 212 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3263
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The synthesis of enantiomerically enriched a-amino acids is described, by means of the diastereoselective conjugate addition of Grignard reagent to (S)-2-acetamidoacrylic ethoxycarbonylphenyl-methyl ester 1 and its N-Boo derivative 5 in the presence of Lewis acids. The addition of magnesium organocu
Asymmetric 1,4 Addition of Grignard Reagents to Chiral α,β-Unsaturated Esters in the Presence of Lewis Acids. -The reaction proceeds with good yields but variable diastereoselectivities, depending on the organometallic reagent and Lewis acid used. -(CARDILLO, GIULIANA;
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