Diastereo- and enantioselective synthesis of allylsilane. A useful C-ring fragment of taxol
โ Scribed by Hiroyuki Kusama; Takeshi Mori; Ikuo Mitani; Hajime Kashima; Isao Kuwajima
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 243 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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An elegant stereocontrolled synthesis of a highly functionalized C ring fragment of taxol ยฎ is d~-ribed. The route utilises a new Diels-Alder reaction followed by regioselective opening ofanhyth'ide, reductive dechlorination, Baeyer-Villiger oxidation of norbornenone system and stereodirected hydrob
A concise synthesis of the oxygen substituted ring A compound 2 found in Taxol w 1a and Taxotere w 1b starting from 2,2dimethylcyclohexane-1,3-dione and proceeding via the key intermediates 8 and 11, is described. The absolute configuration of 2 was established from an X-ray crystal structure determ