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A concise enantioselective synthesis of a fully oxygen substituted ring A taxol precursor

✍ Scribed by Olivier Roy; Gerald Pattenden; David C. Pryde; Claire Wilson

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 154 KB
Volume: 59
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(03)00699-9

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✦ Synopsis

A concise synthesis of the oxygen substituted ring A compound 2 found in Taxol w 1a and Taxotere w 1b starting from 2,2dimethylcyclohexane-1,3-dione and proceeding via the key intermediates 8 and 11, is described. The absolute configuration of 2 was established from an X-ray crystal structure determination of a 4-bromophenylbenzoate derivative, viz. 15.

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