A short synthesis of the A-ring of taxol
β Scribed by Esko K. Karvinen; Ari M.P. Koskinen
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 390 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4020
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π SIMILAR VOLUMES
Absfhzct. The optically active tax01 A-ring unit 3 was synthesized in 11 steps from 2-isopropyl-2-propenol. The stereogenic centers were introduced via the asymmeuic glyoxylateene reaction and the Sharpless asymmetric epoxidation reaction. The total synthesis of tax01 (1) and analogous compounds ha
A fully functionalised synthesis of taxol A-ring, through Michael/Wittig reaction and regioselective opening epoxide as key steps and also a methodology for substituted cyclohexadienes through tandem Michael/WRtig reaction is described.
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