Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas
β Scribed by Chiosea, Simion; Krasinskas, Alyssa; Cagle, Philip T; Mitchell, Kisha A; Zander, Dani S; Dacic, Sanja
- Book ID
- 109887666
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 156 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0893-3952
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Previously we have reported non-random cytogenetic abnormalities involving the short arm of chromosome 9 (9p) in the majority of primary non-small cell lung cancer (NSCLC) patient samples, which indicated loss of DNA sequences. In another lung tumor, pleural malignant mesothelioma (MM), cytogenetic
## Background: The diagnosis of malignant mesothelioma (mm) in serous effusions is difficult but may be achieved by the application of adjuvant methods. ## Methods: The authors cytologically diagnosed 33 effusions as suspicious or positive for mm cells by using dna-image cytometry (dna-icm), immu
## Abstract The __CDKN2A__ tumorβsuppressor gene in chromosome band 9p21 encoding CDKN2A (also known as p16, INK4A), a negative regulator of cyclinβdependent kinases, and p14^ARF1^, an activator of __TP53__, is inactivated in many human cancers by point mutations, promoter hypermethylation, or dele