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Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas

✍ Scribed by Chiosea, Simion; Krasinskas, Alyssa; Cagle, Philip T; Mitchell, Kisha A; Zander, Dani S; Dacic, Sanja


Book ID
109887666
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
156 KB
Volume
21
Category
Article
ISSN
0893-3952

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## Abstract The __CDKN2A__ tumor‐suppressor gene in chromosome band 9p21 encoding CDKN2A (also known as p16, INK4A), a negative regulator of cyclin‐dependent kinases, and p14^ARF1^, an activator of __TP53__, is inactivated in many human cancers by point mutations, promoter hypermethylation, or dele