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Diagnosis of fetal rubella infection by nucleic acid hybridization

✍ Scribed by L. Ho-Terry; Dr. G. M. Terry; P. Londesborough; K. R. Rees; F. Wielaard; A. Denissen

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
412 KB
Volume
24
Category
Article
ISSN
0146-6615

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✦ Synopsis

The efficacy of nucleic acid hybridization for the diagnosis of rubella infection in experimental and clinical materials was compared with immunoblot and virus isolation techniques. Our results showed that nucleic acid hybridization is specific and rapid but gives false-negative results when compared with conventional virus isolation in some experimental although not in clinical materials so far examined. For this reason, a failure to demonstrate rubella virus in fetal specimens by this method alone cannot yet be taken as a sole criterion for ruling out fetal rubella infection.

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