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Developmental programming of CpG island methylation profiles in the human genome

โœ Scribed by Straussman, Ravid; Nejman, Deborah; Roberts, Douglas; Steinfeld, Israel; Blum, Barak; Benvenisty, Nissim; Simon, Itamar; Yakhini, Zohar; Cedar, Howard

Book ID
109965669
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
760 KB
Volume
16
Category
Article
ISSN
1545-9993

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## Abstract It is demonstrated that a heterologous (chicken) CpG island containing five Sp1 canonical recognition sequences becomes highly methylated in the genome of transgenic mice bearing one or several copies of the transgene. Similar levels of methylation of the chicken CpG island were observe