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Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

✍ Scribed by Shukla, Suneet; Wu, Chung-Pu; Ambudkar, Suresh V

Book ID
121080741
Publisher
Informa plc
Year
2008
Tongue
English
Weight
466 KB
Volume
4
Category
Article
ISSN
1742-5255

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Active drug efflux transporters of the ATP binding cassette (ABC)-containing family of proteins have a major impact on the pharmacological behavior of most of the drugs in use today. Pharmacological properties affected by ABC transporters include the oral bioavailability, hepatobiliary, direct intes