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Development of an Improved Rhodium Catalyst for Z -Selective Anti-Markovnikov Addition of Carboxylic Acids to Terminal Alkynes

✍ Scribed by Wei, Siping; Pedroni, Julia; Meißner, Antje; Lumbroso, Alexandre; Drexler, Hans-Joachim; Heller, Detlef; Breit, Bernhard


Book ID
121249730
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
750 KB
Volume
19
Category
Article
ISSN
0947-6539

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Carboxylic acids react with terminal alkynes in the presence of a catalytic amount of RuCl x (p-cymene)(triazol-5-ylidene) to selective generate Z-alk-1-en-1-yl esters. The anti-Markovnikov and trans addition on the terminal alkyne gives access to Z-alkene derivatives of phenylacetylene, t-butylacet