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Development of a sensitive flow-injection–chemiluminescence detection method for the determination of laevodopa

✍ Scribed by Seikh Mafiz Alam; Mohammad Mainul Karim; Sang Hak Lee; Saikh Mohammad Wabaidur; Hye Young Chung; Jong Ha Choi; Meea Kang

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
353 KB
Volume
23
Category
Article
ISSN
1522-7235

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✦ Synopsis

Abstract

A simple chemiluminometric method using flow injection has been developed for the determination of laevodopa, based on its sensitizing effect on the weak chemiluminescence (CL) reaction between Na~2~SO~3~ and acidic KMnO~4~. Under optimum experimental conditions, the CL intensity was linearly related to the concentration of laevodopa from 3.4 × 10^–8^ to 2.4 × 10^–5^ mol/L and the detection limit was 1.1 × 10^–8^ mol/L (s:n = 3). The relative standard deviation (RSD) of the proposed method calculated from 20 replicate injection of 3 × 10^–7^ mol/L laevodopa was 3.3%. The correlation coefficient was 0.997. The method was successfully applied to the determination of laevodopa in commercial pharmaceutical formulations and spiked urine samples. Copyright © 2008 John Wiley & Sons, Ltd.

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