Development of a sensitive assay for the determination of mevalonic acid in urine and its application to clinical studies with rosuvastatin
β Scribed by B. H. Woollen; P. C. Holme; P. D. Martin
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 209 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0009-5893
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A sensitive and selective determination of a-keto acids was established by the use of a gas chromatograph equipped with an electron capture detector. a-Keto acids (pyruvic, oxaloacetic, a-ketobutyric, and a-ketoglutaric acids) were reacted with pentafluorophenylhydrazine, and the derivatives were ex
## Abstract A simple, sensitive and specific LCβMS/MS method for the determination of lipoic acid was developed and validated over the linearity range 5β1000 ng/mL (__r__^2^ > 0.99) with 200 Β΅L rat plasma using rosigliatzone as an internal standard (IS). The assay procedure involved a simple oneβst