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Development of a One-Pot Asymmetric Azaelectrocyclization Protocol: Synthesis of Chiral 2,4-Disubstituted 1,2,5,6-Tetrahydropyridines.

โœ Scribed by Toyoharu Kobayashi; Miyuki Nakashima; Toshikazu Hakogi; Katsunori Tanaka; Shigeo Katsumura


Publisher
John Wiley and Sons
Year
2006
Weight
26 KB
Volume
37
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Ethylcrotonates in
โœ V. D. DYACHENKO; A. A. NIKISHIN; V. P. LITVINOV ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 30 KB ๐Ÿ‘ 2 views

Ethylcrotonates in the Synthesis of 4,4-Disubstituted 3,5-Dicyano-6oxo-1,4,5,6-tetrahydropyridine-2-thiolates. -Michael addition of ethyl crotonate (I) to cyanothioacetamide (II) in the presence of N-methylmorpholine and subsequent in situ cyclization affords the title tetrahydropyridinethiolates as