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Development of a HPTLC method for in-process purity testing of pentoxifylline

✍ Scribed by Olivera Grozdanovic; Dusan Antic; Danica Agbaba

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 445 KB
Volume: 28
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.200400006

No coin nor oath required. For personal study only.

✦ Synopsis

A HPTLC method for the separation and identification of pentoxifylline and related substances, impurities of reaction partners, and side reaction products has been developed using different mobile and stationary phases. For quantitative assay of possible by-products as impurities, LiChrospher RP-18 F254s chromatoplates, acetone-chloroform-toluene-dioxane (2:2:1:1 v/v) as a mobile phase, and detection at 275 nm were employed. Linearity (r > or = 0.997), recovery (86.5-115.5%), and determination limit (0.1-0.6%) were evaluated and found to be satisfactory. This method enables monitoring of the synthesis, as well as purity control of pentoxifylline-containing raw materials and pharmaceuticals.

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