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Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: Application to a clinical pharmacokinetic study

✍ Scribed by D. Vijaya Bharathi; B. Jagadeesh; Kishore Kumar Hotha; Uday Patil; Indu Bhushan

Book ID
116620514
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
826 KB
Volume
879
Category
Article
ISSN
1873-376X

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Highly sensitive method for the determin
Highly sensitive method for the determination of omeprazole in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study
✍ Shivva Vittal; Ramesh Ganneboina; Buddhadev Layek; Ravi Kumar Trivedi; Kishore K 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 705 KB

## Abstract A highly sensitive, rapid assay method has been developed and validated for the estimation of omeprazole (OPZ) in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive‐ion mode. The assay procedure involves alkalinizatio