## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i
Development and validation of a chemical hydrolysis method for dextromethorphan and dextrophan determination in urine samples: Application to the assessment of CYP2D6 activity in fibromyalgia patients
✍ Scribed by Y. Daali; S. Cherkaoui; F. Doffey-Lazeyras; P. Dayer; J.A. Desmeules
- Book ID
- 108159805
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 882 KB
- Volume
- 861
- Category
- Article
- ISSN
- 1873-376X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The validation of a fast, reliable, and specific method for the screening, confirmation, and determination of salbutamol in urine with (total) and without (free fraction) a hydrolysis step was developed. Sample urine from different animal species was extracted using Bond Elut certify columns. The de
## Abstract A sensitive and selective LC‐MS/MS method was developed and validated for the determination of aconitine in microdialysate and rat plasma. Extraction of plasma sample was conducted by use of 1% trichloracetic acid and acetonitrile solution with 10 ng/mL internal standard (propafenone) s