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A method for the simultaneous determination of vitamins D2,D3 and their metabolites in plasma and its application to plasma samples obtained from normal subjects and patients

✍ Scribed by Sonoko Masuda; Toshio Okano; Tadashi Kobayashi


Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
1016 KB
Volume
45
Category
Article
ISSN
0308-8146

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## Abstract Dextromethorphan is used as a probe drug for assessing CYP2D6 and CYP3A4 activity __in vivo__ and __in vitro__. A SIM GC/MS method without derivatization for the simultaneous determination of dextromethorphan and its metabolites, dextrorphan, 3‐methoxymorphinan and 3‐hydroxymorphinan, i