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Development and exploitation of CK2 inhibitors

✍ Scribed by Stefania Sarno; Maria Ruzzene; Pietrogiulio Frascella; Mario A. Pagano; Flavio Meggio; Alfonso Zambon; Marco Mazzorana; Giovanni Di Maira; Vittorio Lucchini; Lorenzo A. Pinna

Publisher
Springer
Year
2005
Tongue
English
Weight
803 KB
Volume
274
Category
Article
ISSN
0300-8177

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A panel of quite specific, fairly potent and cell-permeable inhibitors of protein kinase CK2 belonging to the classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole derivatives and indoloquinazolines have been developed, with K i values in the submicromolar range. Nine structu