Expanding the chemical diversity of CK2 inhibitors
✍ Scribed by Renaud Prudent; Virginie Moucadel; Miriam López-Ramos; Samia Aci; Beatrice Laudet; Liliane Mouawad; Caroline Barette; Jacques Einhorn; Cathy Einhorn; Jean-Noel Denis; Gilles Bisson; Frédéric Schmidt; Sylvaine Roy; Laurence Lafanechere; Jean-Claude Florent; Claude Cochet
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 956 KB
- Volume
- 316
- Category
- Article
- ISSN
- 0300-8177
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A panel of quite specific, fairly potent and cell-permeable inhibitors of protein kinase CK2 belonging to the classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole derivatives and indoloquinazolines have been developed, with K i values in the submicromolar range. Nine structu