New inhibitors of protein kinase CK2, analogues of benzimidazole and benzotriazole
✍ Scribed by Maria Bretner; Andzelika Najda-Bernatowicz; Maja Łebska; Grażyna Muszyńska; Anna Kilanowicz; Andrzej Sapota
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 167 KB
- Volume
- 316
- Category
- Article
- ISSN
- 0300-8177
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## Abstract Abnormally high constitutive activity of protein kinase CK2, levels of which are elevated in a variety of tumours, is suspected to underlie its pathogenic potential. The most widely employed CK2 inhibitor is 4,5,6,7‐tetrabromobenzotriazole (TBB), which exhibits a comparable efficacy tow
Protein kinase CK2, formerly known as casein kinase II, is a ubiquitous protein serine/threonine kinase. The enzyme exists in tetrameric complexes composed of two catalytic (CK2a and/or CK2a8) subunits and two subunits (CK2b) that appear to have a role in modulating the activity of the catalytic sub