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Structure-based discovery of novel flavonol inhibitors of human protein kinase CK2

✍ Scribed by Andriy G. Golub; Volodymyr G. Bdzhola; Yaroslav V. Kyshenia; Vladislav M. Sapelkin; Andriy O. Prykhod’ko; Olexander P. Kukharenko; Olga V. Ostrynska; Sergiy M. Yarmoluk

Publisher
Springer
Year
2011
Tongue
English
Weight
656 KB
Volume
356
Category
Article
ISSN
0300-8177

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Structure-Based Pharmacophore Modeling from Multicomplex: a Comprehensive Pharmacophore Generation of Protein Kinase CK2 and Virtual Screening Based on it for Novel Inhibitors
✍ Hao-Peng Sun; Jia Zhu; Fei-Hong Chen; Qi-Dong You 📂 Article 📅 2011 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 883 KB

## Abstract Protein kinase CK2, a member of the serine/threonine kinase family, is an attractive therapeutic target for anticancer combination therapy. A multiple structure‐based modeling approach complemented with shape components was taken to build a reliable pharmacophore model for ATP‐competiti