✦ LIBER ✦

Development and comparison of thin-layer chromatographic and gas—liquid chromatographic methods for measurement of methimazole in rat urine

✍ Scribed by J.B. Stenlake; W.D. Williams; G.G. Skellern

Publisher: Elsevier Science
Year: 1970
Tongue: English
Weight: 613 KB
Volume: 53
Category: Article
ISSN: 1873-3778
DOI: 10.1016/s0021-9673(01)98469-9

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✦ Synopsis

Thin-layer chromatographic and gas-liquid chromatographic methods have been developed for the measurement of methimazole in rat urine. Of the two methods, gas-liquid chromatography is the more sensitive, but because of the instability of the derivative which is used, replicate measurements must be made on the same day. The densitometric method is less sensitive because of interference by endogenous matter, but is more rapid and hence better suited to routine use.

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