𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Development and Application of Physiologically Based Pharmacokinetic-Modeling Tools to Support Drug Discovery

✍ Scribed by Christian Lüpfert; Andreas Reichel


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
636 KB
Volume
2
Category
Article
ISSN
1612-1872

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


An evaluation of the utility of physiolo
✍ Neil Parrott; Nicolas Paquereau; Philippe Coassolo; Thierry Lavé 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 494 KB

Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and

A priori prediction of tissue:plasma par
✍ Patrick Poulin; Frank-Peter Theil 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB 👁 3 views

The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib