Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from six chemical classes. Input data consisted of structure based predictions of lipophilicity, ionization, and
✦ LIBER ✦
Development and Application of Physiologically Based Pharmacokinetic-Modeling Tools to Support Drug Discovery
✍ Scribed by Christian Lüpfert; Andreas Reichel
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 636 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1612-1872
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The tissue:plasma (P t:p ) partition coefficients (PCs) are important drugspecific input parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the disposition of drugs in biota. Until now the use of PBPK models in early stages of the drug discovery process was not possib