Deuterium NMR cerebral imaging in Situ

✍ Scribed by Coleen S. Ewy; Joseph J. H. Ackerman; Robert S. Balaban

• Book ID: 102953365
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 662 KB
• Volume: 8
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910080105

✦ Synopsis

Nuclear magnetic resonance imaging of deuterium is demonstrated in cat brain in vivo and in situ at 4.7 T magnetic field strength. Images were acquired at 4-5% deuterium enrichment, using D20 as a nuclear spin label, with as little as 10-s time resolution. This suggests the potential application of D 2 0 as an exogenous MRI label for quantitative flow imaging or contrast enhancement. The efficient quadrupolar relaxation mechanism of the deuterium nuclide results in a short ca. 250 ms spin-lattice relaxation time ( T I ) . This allows for rapid signal averaging, thus increasing signal-to-noise in the deuterium image. Additionally, three widely dispersed deuterium spin-spin relaxation times ( T2) are observed of ca. 10, 40, and 400 ms which provide high compartmental image contrast, thus yielding information of physiological as well as anatomical interest. T2-weighted deuterium cerebral images are presented showing marked tissue relaxation discrimination.