๐”– Bobbio Scriptorium
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In situ assessment of tumor vascularity using fluorine nmr imaging

โœ Scribed by Toni L. Ceckler; Scott L. Gibson; Russell Hilf; Robert G. Bryant

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
935 KB
Volume
13
Category
Article
ISSN
0740-3194

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โœฆ Synopsis

Abstract

In situ fluorine NMR imaging has been used to measure vascularity in subcutancously implanted mammary tumors. Oxyferol, a perfluorinated blood substitute comprised of an emulsion of 25% w/v perfluorotributylamine, was used as a tracer. Following iv administration, this perfluorocarbon emulsion remains primarily in the vasculature during the image acquisition period. The distribution of the PFTA in the ^19^F NMR image gives a map of tissue regions with intact vascularity. This technique has been used to demonstrate decreased blood flow in necrotic regions of R3230AC mammary tumors in which vasculature had been damaged either as a result of spontaneous necrosis or by photodynamic therapy (PDT). Damage to tumor vascularity following PDT was observed prior to the development of necrosis.

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