Deuterium isotope effect on the enzymatic oxidation of dopamine and serotonin
β Scribed by Peter H. Yu; Clem Kazakoff; Bruce A. Davis; Alan A. Boulton
- Book ID
- 115776544
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 172 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0006-2952
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A solvent deuterium isotope effect on the catalytic affinity (K(m)) and rate constant (k(cat)) of tyrosinase in its action on 4-tert-butylcatechol (TBC) was observed. Both parameters decreased as the molar fraction of deuterated water in the medium increased, while the k(cat)/K(m) ratio remained con
PHENYL trifluoromethyl carbinols are oxidized by aqueous alkaline permsnganate to the corresponding ketones. We wish to report a kinetic isotope effect of unusual size for the reaction of the 1-deuterio analogs of these compounds. YC6H4CDOHCF3 + 2Mn04-+ 2OH-4 YC H COCF3 + 2Mn0 \* + H20 + RDO 64 4 1-