𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Deuterated organic compounds XXV synthesis of 1, 4, 5, 8-tetradeuterionaphthalene

✍ Scribed by R. N. Renaud; L. C. Leitch

Publisher
John Wiley and Sons
Year
1965
Tongue
French
Weight
489 KB
Volume
1
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

1,4,5,8-Tetradeuterionaphthalene was synthesized from 1 ,Cdibromonaphthalene by two methods. In the first method naphthalene was repeatedly brominated in chloroform and then debrominated with zinc dust in alkaline deuterium oxide. In the second, 1,4-dibromonaphthaIene was nitrated to produce 1,4-dibrorno-5-nitronaphthalene which underwent reductive debromination with zinc in alkaline deuterium oxide to l-amino-5,8-dideuterionaphthalene. The latter was converted into l-bromo-5,8-dideuterionaphthalene by a modified Sandmeyer reaction which was brominated to 1,Cdibromo-5&dideuterionaphthalene and then debrominated to 1,4,5,8-tetradeuterio-*

📜 SIMILAR VOLUMES

Synthesis and Properties of 1,4,5,8-Anth
Synthesis and Properties of 1,4,5,8-Anthradiquinone
✍ Priv.-Doz. Dr. P. Boldt; Dipl.-Chem. F. Vardakis 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 1 views

To a cold (-78'C) solution of 10 mmoles of the iithium derivative ( I ) , RI=CH3, in tetrahydrofuran 111 was added with stirring 1.06 g (10 mmoles) of benzonitrile. The resulting bright orange mixture was kept at -78 O C for 40 min, after which the bath was removed and stirring was continued for an

Synthesis of substituted pyrimido[4,5-b]
Synthesis of substituted pyrimido[4,5-b] and [5,4-c]-[1,8]naphthyridines
✍ Christophe Plisson; Jacques Chenault 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 56 KB

## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.

Synthesis of [1′,3′,4′-3H3]4-(5′,6′,7′,8
Synthesis of [1′,3′,4′-3H3]4-(5′,6′,7′,8′-tetrahydro-5′,5′,8′,8′-tetramethyl-2′-anthracenyl)benzoic acid for binding studies of retinoic acid receptors
✍ Marcia I. Dawson; Peter D. Hobbs; Sung W. Rhee; Hiromi Morimoto; Philip G. Willi 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 French ⚖ 260 KB

## Abstract [1′,3′,4′‐^3^H~3~]4‐(5′,6′,7′,8′‐Tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid (specific activity 64 Ci/mmole) was synthesized by bromination of ethyl 4‐(5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐antracenyl)benzoate, followed by reductive debromination by tritiu