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Synthesis of [1′,3′,4′-3H3]4-(5′,6′,7′,8′-tetrahydro-5′,5′,8′,8′-tetramethyl-2′-anthracenyl)benzoic acid for binding studies of retinoic acid receptors

✍ Scribed by Marcia I. Dawson; Peter D. Hobbs; Sung W. Rhee; Hiromi Morimoto; Philip G. Williams

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
260 KB
Volume
33
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[1′,3′,4′‐^3^H~3~]4‐(5′,6′,7′,8′‐Tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐anthracenyl)benzoic acid (specific activity 64 Ci/mmole) was synthesized by bromination of ethyl 4‐(5′,6′,7′,8′‐tetrahydro‐5′,5′,8′,8′‐tetramethyl‐2′‐antracenyl)benzoate, followed by reductive debromination by tritium gas in the presence of 10% palladium on carbon and hydrolysis. ^1^H and ^3^H NMR spectroscopy was used to establish tritium at 1′,3′,4′‐tetrahydroanthracenyl ring positions.

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