During thymic development, immature T cells rearrange and express the genes encoding the T-cell antigen receptor and mature as either o~1~ or '{8 lineage T cells. In the past year, advances have been made in understanding the role of individual components of the T-cell antigen receptor complex in th
✦ LIBER ✦
Determining γδ versus αβ T cell development
✍ Scribed by Ciofani, Maria; Zúñiga-Pflücker, Juan Carlos
- Book ID
- 109956361
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 419 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2820
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~6 T cells consist of multiple lineages of cells with distinct antigen receptor repertoires, tissue localization and function. Recent evidence suggests that the ordered appearance of these sublineages during development is a result of programed rearrangement of Vy-gene segments. It appears that the