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Determination of therapeutic oligonucleotides using capillary gel electrophoresis

✍ Scribed by Buyun Chen; Michael G. Bartlett

Book ID
118753644
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
264 KB
Volume
26
Category
Article
ISSN
0269-3879

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πŸ“œ SIMILAR VOLUMES

Analysis of oligonucleotides by capillar
Analysis of oligonucleotides by capillary gel electrophoresis
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Analysis of oligonucleotides with gel-filled capillary columns is a fast, efficient and automated way to check their purity. Gel-filled columns were optimized to separate oligonucleotides which were 2&50 nucleotides in length. The influence of sample size on resolution is discussed. A comparison bet

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## Abstract Recently, several therapeutic double‐stranded (ds) oligonucleotides (ODNs) are in pharmaceutical development. During quality control, these therapeutic molecules have to be characterized with respect to their identity, their content and their impurity profile. It follows that the ds mol

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Diffusion coefficients of oligonucleotides in capillary gel electrophoresis
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## Abstract Diffusion coefficients of oligonucleotides have been measured in polyacrylamide gel capillaries without application of an electrical field. A relationship between such diffusion coefficients and molecular size of the oligonucleotides could be achieved. The slower diffusion of larger oli