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Determination of terephthalic acid isopropylamide in urine with a liquid chromatography/mass spectrometry (LC/MS) method

✍ Scribed by F. Baumann; C. Mauz-Körholz; D. Clauß; S. Borrmann; A. Giannis; N. Merkel; D. Körholz; R. Preiss

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
165 KB
Volume
22
Category
Article
ISSN
0887-8013

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✦ Synopsis

Abstract

A sensitive and simple liquid chromatography/mass spectrometry (LC/MS) method was developed for the determination of terephthalic acid isopropylamide, the final metabolite of procarbazine in human urine. A solid‐phase extraction with C~18~ cartridges was used followed by LC/MS with a single mass spectrometer (SSQ 7000 from Finnigan). Terephthalic acid isobutylamide was the internal standard. The quantification limit was 30 ng/mL in urine (6 × noise). This assay was applied for drug monitoring of terephthalic acid isopropylamide in urine after oral administration of procarbazine in children and adolescents with Hodgkin lymphomas. J. Clin. Lab. Anal. 22:21–28, 2008. © 2008 Wiley‐Liss, Inc.

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