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Determination of serum methotrexate and 7-hydroxymethotrexate concentrations: Method evaluation showing advantages of high-performance liquid chromatography

✍ Scribed by Nellie So; David P. Chandra*; Ion S. Alexander; Valerie J. Webster; Darcy W. O'Gorman Hughes


Publisher
Elsevier Science
Year
1985
Weight
666 KB
Volume
337
Category
Article
ISSN
0378-4347

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7-Methylguanine (m'Gua), N\*,N\*-dimethylguanosine (m:Guo), and pseudouridine ($) are degradation products from RNA turnover and can be used as markers for the whole-body turnover of mRNA-cap, tRNA, and rRNA (in healthy individuals, urinary excretion of these catabolites follows a regular pattern; t