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Determination of plasma concentrations of epirubicin and its metabolites by high-performance liquid chromatography during a 96-h infusion in cancer chemotherapy

✍ Scribed by Ian K. Barker; S. Michael Crawford; Anthony F. Fell

Publisher
Elsevier Science
Year
1996
Weight
444 KB
Volume
681
Category
Article
ISSN
0378-4347

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Rapid quantitative determination of epir
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A rapid sensitive and selective isocratic technique was developed for the analysis of plasma epirubicin and three of its known fluorescent metabolites epirubicinol, 4'-O-~-~-glucuronyl-4'-epidoxorubicin and 4'-O-fi-D-ghCUrOnyl 1,3-dihydro-4'-epidoxorubicin, with daunorubicin as an internal standard,