Efficient determination of the pKa value
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P. Chaminade; A. Baillet; D. Ferrier; B. Bourguignon; D.L. Massart
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Article
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1993
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Elsevier Science
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English
β 614 KB
A non-linear regression algorithm is used to compute acidity constants from capacity factors recorded at various pH values using a standard reversed-phase column and acetonitrile as organic modifier . An application is presented for six chlorophenols and the pKa values calculated for those compounds