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Efficient determination of the pKa values of six chlorinated phenols by reversed-phase liquid chromatography

✍ Scribed by P. Chaminade; A. Baillet; D. Ferrier; B. Bourguignon; D.L. Massart

Book ID
102984190
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
614 KB
Volume
280
Category
Article
ISSN
0003-2670

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✦ Synopsis

A non-linear regression algorithm is used to compute acidity constants from capacity factors recorded at various pH values using a standard reversed-phase column and acetonitrile as organic modifier . An application is presented for six chlorophenols and the pKa values calculated for those compounds compare favourably with literature data obtained by other methods in aqueous media. This pKa determination method is also suitable for mobile phase optimization; a resolution map based on pK a values from the literature and liquid chromatography-related pKa values is presented .

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