A sensitive and selective method for the determination of a-cyclodextrin in human plasma is described using b-cyclodextrin as an internal standard. After protein precipitation with perchloric acid, the analytes were isolated from human plasma by solid-phase extraction on Bond Elut C 18 cartridges. T
Determination of organotins in water by micro liquid chromatography–electrospray/ion trap mass spectrometry
✍ Scribed by Tammy L. Jones-Lepp; Katrina E. Varner; Mark McDaniel; Lee Riddick
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 112 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0268-2605
No coin nor oath required. For personal study only.
✦ Synopsis
Due to the varying toxicity the species of organotins in their widespread applications, it is important for analytical methods to address their speciation. Traditional methods call for the hydrolysis and subsequent derivatization of the organotins before analysis. These methods can be time-consuming, derivatization can be incomplete and high levels of background interference produce difficulties in identification and quantification. The use is described of a nonderivatization and non-hydrolysis micro-liquid chromatography-electrospray/ion trap mass spectrometry for separation and detection of the organotins.
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