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Determination of monoureides in biological fluids by high-pressure-liquid-chromatography

✍ Scribed by Michel Eichelbaum; Bärbel Sonntag; Gerd Unruh

Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
639 KB
Volume
41
Category
Article
ISSN
0340-5761

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✦ Synopsis

A sensitive and specific method for the simultaneous determination of bromisoval, carbromal, and methaqualone is described. The drugs are adsorbed from serum onto charcoal at pH 11 and eluted from it with organic solvent. The eluate is separated by high-pressure liquid-chromatography on reverse phase (RP 18) column using acetonitrile: water (26 : 74 by volume) as mobile phase. The eluted drugs are detected by uv-absorption at 210 nm. The method is sensitive, specific, precise, and accurate.

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