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Determination of midazolam and its unconjugated 1-hydroxy metabolite in human plasma by high-performance liquid chromatography

✍ Scribed by B. Lehmann; R. Boulieu

Publisher: Elsevier Science
Year: 1995
Weight: 257 KB
Volume: 674
Category: Article
ISSN: 0378-4347
DOI: 10.1016/0378-4347(95)00286-6

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## Abstract A sensitive gas liquid chromatographic (GLC) assay was developed for plasma determinations of 8‐chloro‐6‐(2′ ‐fluorophenyl)‐1‐methyl‐4__H__‐imidazo[1,5 α][1,4]benzodiazepine (compound I) and its hydroxymethylimidazo metabolite (compound II). The internal standards used were 8‐chloro‐6‐(