Determination of imipenem and cilastatin in serum and tissue by high-pressure liquid chromatography
β Scribed by Rea Krausse; U. Ullmann
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 229 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0300-8126
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π SIMILAR VOLUMES
A simple and reliable HPLC method is described for the new beta-lactam antibiotic imipenem; suitable extraction procedures for the drug in human plasma, urine and prostatic tissue are described. The figures of merit for the assays are reported and examples given of their application.
A quantitative high-pressure liquid chromatographic method has been developed for the analysis of hydrochlorothiazide in serum in therapeutical concentrations. The method is based on gel filtration of the sera on Sephadex G-15, extraction of the protein-free fraction of the efHuent with ethyl acetat